BDBM350330 (S,E)-5-(1-((1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US10307414, Example 14::US9801872, Example 14

SMILES CN(C)C\C=C\C(=O)N1CC[C@@H](C1)Oc1nc(cc2ccccc12)-c1n[nH]c(=O)[nH]1

InChI Key InChIKey=LYLIIVFLUFYWEH-PXTSUWAFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350330   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350330((S,E)-5-(1-((1-(4-(dimethylamino)but-2-enoyl)pyrro...)
Affinity DataIC50:  6.31nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350330((S,E)-5-(1-((1-(4-(dimethylamino)but-2-enoyl)pyrro...)
Affinity DataIC50:  6.31nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent