BDBM354912 1-Methylcyclopropanamine Oxalate::US9815796, Example 3

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)NC2(CC2)c2ccc(cc2)C(F)(F)F)cc1OC

InChI Key InChIKey=RULZPHGWLAEJQG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354912   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM354912(1-Methylcyclopropanamine Oxalate | US9815796, Exam...)
Affinity DataKi:  0.450nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM354912(1-Methylcyclopropanamine Oxalate | US9815796, Exam...)
Affinity DataKi:  0.540nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent