BDBM354913 2-Methyl-2-(1H-pyrazol-1-yl)propanimidamide acetate::US9815796, Example 4

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C)c2ccc(cc2)C(F)(F)F)cc1OC

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354913   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM354913(2-Methyl-2-(1H-pyrazol-1-yl)propanimidamide acetat...)
Affinity DataKi:  0.520nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM354913(2-Methyl-2-(1H-pyrazol-1-yl)propanimidamide acetat...)
Affinity DataKi:  0.560nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent