BDBM355418 N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)phenyl]propyl}- 2-(3-fluoro-4-methoxybenzyl)-6- oxo-1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 509

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355418   

TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355418(N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...)
Affinity DataKi:  0.880nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355418(N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...)
Affinity DataKi:  0.990nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent