BDBM355437 2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]propyl}- 6-oxo-1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 528

SMILES CC[C@@H](NC(=O)c1cc(=O)[nH]c(Cc2ccc(OC)c(F)c2)n1)c1ccc(OC(F)(F)F)c(F)c1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355437   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355437(2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...)
Affinity DataKi:  1.10nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355437(2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...)
Affinity DataKi:  1.20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent