BDBM358857 N-(2-methoxyethyl)-3-[4-(morpholin-4-yl)furo[3,2-c]pyridin-2-yl]imidazo[1,2-b]pyridazine-6-carboxamide::US10214545, Example 6

SMILES COCCNC(=O)c1ccc2ncc(-c3cc4c(nccc4o3)N3CCOCC3)n2n1

InChI Key InChIKey=WGGGLERYINLRRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358857   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358857(N-(2-methoxyethyl)-3-[4-(morpholin-4-yl)furo[3,2-c...)
Affinity DataIC50:  12nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358857(N-(2-methoxyethyl)-3-[4-(morpholin-4-yl)furo[3,2-c...)
Affinity DataIC50:  4.60nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent