BDBM359736 7-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2,2,4-trimethyl-2,3-dihydrobenzofuran-5-carboxamide::US9822103, Example 7

SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)c3OC(C)(C)Cc3c2C)c(=O)[nH]1

InChI Key InChIKey=UTHUYNBXIPIADY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359736   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM359736(7-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-...)
Affinity DataIC50:  750nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent