BDBM360022 N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-3-isopropylpyrazolo[1,5-a]pyrimidine-5-carboxamide::US9822124, Example 82

SMILES CC(C)c1cnn2ccc(nc12)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key InChIKey=SFPWQRNDHZDANZ-XHSDSOJGSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 360022   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM360022(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM360022(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50:  30nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM360022(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50:  5.50E+3nMAssay Description:Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent