BDBM362418 4-(7-amino-3- {(3R,6S)-1-[(2S)-2- hydroxypropanoyl]- 6-methylpiperidin-3-yl}- 1H-pyrazolo[3,4-c]pyridin-1-yl)- N-(4-cyclopropylpyridin-2- yl)benzamide::US9834554, Example 32

SMILES C[C@H](O)C(=O)N1C[C@@H](CC[C@@H]1C)c1nn(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C2CC2)c2c(N)nccc12

InChI Key InChIKey=ROJDULCOFTZLOA-NPPFBWRTSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362418   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362418(4-(7-amino-3- {(3R,6S)-1-[(2S)-2- hydroxypropanoyl...)
Affinity DataIC50:  1.60nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent