BDBM364373 US9862688, Compound 1

SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(CCNC(=O)CC2[C@H]3CC4C[C@@H](C[C@@H]2C4)C3)CC1

InChI Key InChIKey=FSWBGVBPIRUITJ-HBPSMINDSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 364373   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  55.5nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  482nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  4.04E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUMP-CMP kinase(Homo Sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  7.26E+5nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  2.99E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  7.95E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364373(US9862688, Compound 1)
Affinity DataIC50:  8.34E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent