BDBM364422 US9862688, Compound 7

SMILES Clc1cnc(Nc2cnn(c2)C2CCN(CCNC(=O)CC3[C@H]4C[C@@H]5C[C@H](C[C@@H]3C5)C4)CC2)nc1NCc1cccc(NC(=O)C=C)c1

InChI Key InChIKey=XGSZJYQCCGRXPI-AXVKBXRTSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 364422   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  6.80nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  105nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  2.28E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  1.44E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  794nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364422(US9862688, Compound 7)
Affinity DataIC50:  954nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent