BDBM364443 2-chloro-N-[5-(hydroxymethyl)-2- phenyl-2H-pyrazolo[4,3-b]pyridin- 3-yl]-5-pyrimidin-2-yl-4- (trifluoromethyl)benzamide::US9862707, Example 17

SMILES OCc1ccc2nn(c(NC(=O)c3cc(-c4ncccn4)c(cc3Cl)C(F)(F)F)c2n1)-c1ccccc1

InChI Key InChIKey=NRBMTQFGYWJGBX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364443   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364443(2-chloro-N-[5-(hydroxymethyl)-2- phenyl-2H-pyrazol...)
Affinity DataIC50:  18nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent