BDBM365023 N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaacenaphthylen-7- yl)pyrimidin-2-amine::US10278975, Compound I-2 S::US11376260, Example I-2S::US9867833, Compound I-2(S)

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@H](Cc3ccccc3)c3nnc(c1)n23

InChI Key InChIKey=BANNDVQQTGYFLM-KRWDZBQOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 365023   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365023(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Affinity DataIC50:  0.380nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365023(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Affinity DataIC50:  0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365023(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Affinity DataIC50:  0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365023(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Affinity DataIC50:  0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent