BDBM36537 2-phenoxylphenol::PT51::US10071965, Compound PT51
SMILES Oc1ccccc1Oc1ccccc1
InChI Key InChIKey=KDTZBYPBMTXCSO-UHFFFAOYSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 36537
Affinity DataKi: 0.5nMAssay Description:Inhibition of wild type Escherichia coli FabI assessed as inhibition of bacterial growthMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Stony Brook University
Stony Brook University
Affinity DataKi: 18.9nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Stony Brook University
Stony Brook University
Affinity DataKi: 18.9nM ΔG°: -10.5kcal/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
Affinity DataKi: 2.26E+3nM ΔG°: -7.70kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition constant binding to E-NAD+More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Stony Brook University
Stony Brook University
Affinity DataKi: 2.45E+4nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair