BDBM365732 6-{(3S,4R)-4-[1-(2-Dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-5-isopropyl-pyrimidin-4-ylamine::US9867826, Compound 31

SMILES CC(C)c1c(N)ncnc1N1CC[C@@H]([C@H](F)C1)c1nc(cn1CCN(C)C)-c1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=AUWAFCLIMMJGIZ-FXAWDEMLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 365732   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM365732(6-{(3S,4R)-4-[1-(2-Dimethylamino-ethyl)-4-(4-fluor...)
Affinity DataIC50: >10nMAssay Description:AKT: A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose respon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1 [T412E](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM365732(6-{(3S,4R)-4-[1-(2-Dimethylamino-ethyl)-4-(4-fluor...)
Affinity DataIC50:  5.5nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent