BDBM368463 US10227342, Example 91
SMILES CNC(=O)c1c(-c2ccnc(Nc3cc(NC(=O)C=C)c(cc3OC)N(C)CCN(C)C)n2)c2ccccc2n1C
InChI Key InChIKey=KPZASAOQJPELDP-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 368463
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Ariad Pharmaceuticals
US Patent
Ariad Pharmaceuticals
US Patent
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair