BDBM372975 3-(fluoromethyl)-5-[6-::US10246432, Example 16::US10584111, Ex No. 16::US11584732, Example 16

SMILES FCc1cc(cc(c1)-c1cc(ncn1)-n1cccn1)C#N

InChI Key InChIKey=XDAOMVUYXZMIBA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372975   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372975(3-(fluoromethyl)-5-[6- | US10246432, Example 16 | ...)
Affinity DataKi:  6.76nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372975(3-(fluoromethyl)-5-[6- | US10246432, Example 16 | ...)
Affinity DataKi:  6.76nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372975(3-(fluoromethyl)-5-[6- | US10246432, Example 16 | ...)
Affinity DataKi:  6.76nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent