BDBM373541 1-[4-Dimethylamino-6-(2,6-dimethyl-phenoxy)-7-fluoro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid;::US10246442, Example 3::US10975062, Example 3

SMILES CN(C)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O

InChI Key InChIKey=SQTKMBVWTXDGSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373541   

TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM373541(1-[4-Dimethylamino-6-(2,6-dimethyl-phenoxy)-7-fluo...)
Affinity DataIC50:  63.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1 [182-426](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373541(1-[4-Dimethylamino-6-(2,6-dimethyl-phenoxy)-7-fluo...)
Affinity DataIC50:  63.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent