BDBM374712 12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,15-ethenopyrazolo[4,3-f][1,10,4,8] benzodioxadiazacyclotridecin-4(5H)-one::US10246466, Example 11-1::US10618912, Example 11-1

SMILES CC1Oc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2

InChI Key InChIKey=YMRTYJKGNCAGKP-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 374712   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374712(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent