BDBM374712 12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,15-ethenopyrazolo[4,3-f][1,10,4,8] benzodioxadiazacyclotridecin-4(5H)-one::US10246466, Example 11-1::US10618912, Example 11-1
SMILES CC1Oc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
InChI Key InChIKey=YMRTYJKGNCAGKP-UHFFFAOYSA-N
Data 6 Kd
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 374712
Affinity DataKd: 1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics
US Patent
Turning Point Therapeutics
US Patent
Affinity DataKd: 1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Affinity DataKd: 1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics
US Patent
Turning Point Therapeutics
US Patent
Affinity DataKd: 1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair