BDBM375280 US10597387, Compound (I-3)::US9908872, Compound (I-3)

SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(NC(=O)c3cncc(c3)-c3cccs3)c2)cc(c1)C(F)(F)F

InChI Key InChIKey=QASQEQBXMMXTAK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 375280   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM375280(US10597387, Compound (I-3) | US9908872, Compound (...)
Affinity DataIC50:  196nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM375280(US10597387, Compound (I-3) | US9908872, Compound (...)
Affinity DataIC50:  62.2nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM375280(US10597387, Compound (I-3) | US9908872, Compound (...)
Affinity DataIC50:  196nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor subfamily 2 group C member 2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM375280(US10597387, Compound (I-3) | US9908872, Compound (...)
Affinity DataIC50:  62.2nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent