BDBM375968 US10947243, Example 47::US9914735, Example 47

SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnn(c1)C1CCOCC1)[C@H]1CNC(=O)C1

InChI Key InChIKey=VJCGVSJYRUABTA-GDBMZVCRSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 375968   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  6.70nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  2.60E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  4.77E+3nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [342-635](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  6.70nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  2.60E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375968(US10947243, Example 47 | US9914735, Example 47)
Affinity DataIC50:  4.77E+3nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent