BDBM377001 6-Fluoro-8-(2-methoxyphenyl)-N-[4-(piperidin-4-yl)-2,3-dihydro-1-benzofuran-7-yl]quinazoline-2-amine ::US10259816, Compound 22::US10611770, Compound 22

SMILES COc1ccccc1-c1cc(F)cc2cnc(Nc3ccc(C4CCNCC4)c4CCOc34)nc12

InChI Key InChIKey=QCJIOPQYKRWUJO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377001   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM377001(6-Fluoro-8-(2-methoxyphenyl)-N-[4-(piperidin-4-yl)...)
Affinity DataIC50:  34nMAssay Description:Buffer preparation: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.The compound was configured as a concentration gradient in 100% DMSO and added to a 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM377001(6-Fluoro-8-(2-methoxyphenyl)-N-[4-(piperidin-4-yl)...)
Affinity DataIC50:  34nMAssay Description:Buffer preparation: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.The compound was configured as a concentration gradient in 100% DMSO and added to a 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent