BDBM379025 2-(1-{2,6-difluoro- 4-[(1E)-prop-1-en- 1-yl]benzyl}-1H- indazol-3-yl)-5- methoxy-N- (pyridin-4- yl)pyrimidin-4- amine::US10266548, Example 6-2

SMILES COc1cnc(nc1Nc1ccncc1)-c1nn(Cc2c(F)cc(\C=C\C)cc2F)c2ccccc12

InChI Key InChIKey=VUWSGFLVLVWWCD-ZZXKWVIFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 379025   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM379025(2-(1-{2,6-difluoro- 4-[(1E)-prop-1-en- 1-yl]benzyl...)
Affinity DataIC50:  7.40nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent