BDBM383374 (S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyrimidin-4-yl)]- 8,9-dihydro-7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-9- yl)butanenitrile::US10278975, Compound I-105 S

SMILES CCC(C#N)[C@H]1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=CYZNMCWEXWUOBS-AWKYBWMHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383374   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM383374((S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyr...)
Affinity DataIC50:  0.0820nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM383374((S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyr...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent