BDBM387194 5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-N-cyclopropylhexahydrocyclopenta[c]pyrrole-2(1H)-sulfonamide::US9938257, Example 47

SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1

InChI Key InChIKey=GTWKARFQAYQPGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387194   

TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387194(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Affinity DataIC50:  0.600nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387194(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Affinity DataIC50:  7nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent