BDBM389506 US9951027, 3-140
SMILES CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2CCCC(C)(C)C2)cc1
InChI Key InChIKey=OLHNTPMHCBIKOT-HXUWFJFHSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 389506
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 20nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair