BDBM392799 2-(4-phenoxyphenyl)-6-(4-(vinylsulfonyl)piperazin-1-yl)nicotinamide::US10301297, Example 62::US11345695, Example 62::US11840513, Example 62

SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)S(=O)(=O)C=C

InChI Key InChIKey=TVVGIVUDWNGTBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 392799   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM392799(2-(4-phenoxyphenyl)-6-(4-(vinylsulfonyl)piperazin-...)
Affinity DataIC50: <500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM392799(2-(4-phenoxyphenyl)-6-(4-(vinylsulfonyl)piperazin-...)
Affinity DataIC50: <500nMAssay Description:The activity of the Examples and Analogs described herein, as inhibitors of BTK are demonstrated and confirmed by pharmacological in vitro assays. Ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM392799(2-(4-phenoxyphenyl)-6-(4-(vinylsulfonyl)piperazin-...)
Affinity DataIC50: <500nMAssay Description:1x and 2x assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent