BDBM393326 4-(((1S,3S)-3-Isothiocyanatocyclobutoxy)methyl)-4'-methyl-1,1'-biphenyl::US9963444, Example 29

SMILES Cc1ccc(cc1)-c1ccc(CO[C@H]2C[C@H](C2)N=C=S)cc1

InChI Key InChIKey=LPNNWYRGSJSHIN-KDURUIRLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393326   

TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393326(4-(((1S,3S)-3-Isothiocyanatocyclobutoxy)methyl)-4'...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393326(4-(((1S,3S)-3-Isothiocyanatocyclobutoxy)methyl)-4'...)
Affinity DataIC50:  55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent