BDBM394352 N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)phenyl]-1-[2- (dimethylamino)-2-oxo-ethyl]pyrazol- 4-yl]pyrazolo[1,5-a]pyrimidine-3- carboxamide::US10307426, Example 6

SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)F

InChI Key InChIKey=UECUGXBRGMZNLD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394352   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394352(N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...)
Affinity DataKi:  0.150nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394352(N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent