BDBM395278 1-Methyl-N-4-[[(4aS,5aS) or (4aR,5aR)]-5a-methyl-4-oxo-3-(phenylamino)-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indol-2-yl]pyridin-2-yl-1H-pyrazole-5-carboxamide::US10308629, Example 42::US10308629, Example 43

SMILES Cn1nccc1C(=O)Nc1cc(ccn1)-c1[nH]c2C[C@]3(C)C[C@@H]3C(=O)c2c1Nc1ccccc1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395278   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395278(1-Methyl-N-4-[[(4aS,5aS) or (4aR,5aR)]-5a-methyl-4...)
Affinity DataIC50:  22nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395278(1-Methyl-N-4-[[(4aS,5aS) or (4aR,5aR)]-5a-methyl-4...)
Affinity DataIC50:  11nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent