BDBM398133 4-chloro-N—(((S)-3, 3-difluorocyclohexyl)methyl)-1-(oxetan-3-yl)-1H-indole-3-carboxamide::US10323000, Compound 67::US10676433, Compound 67

SMILES FC1(F)CCC[C@H](CNC(=O)c2cn(C3COC3)c3cccc(Cl)c23)C1

InChI Key InChIKey=OYWYCRPFZPTSLP-LBPRGKRZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 398133   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398133(4-chloro-N—(((S)-3, 3-difluorocyclohexyl)meth...)
Affinity DataIC50:  55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398133(4-chloro-N—(((S)-3, 3-difluorocyclohexyl)meth...)
Affinity DataIC50:  55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398133(4-chloro-N—(((S)-3, 3-difluorocyclohexyl)meth...)
Affinity DataIC50:  55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398133(4-chloro-N—(((S)-3, 3-difluorocyclohexyl)meth...)
Affinity DataIC50:  55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent