BDBM398177 4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(tetrahydrofuran-3-yl)-1H-indole-3-carboxamide::US10323000, Compound 114::US10676433, Compound 114

SMILES FC1(F)CCC(CNC(=O)c2cn(C3CCOC3)c3cccc(Cl)c23)CC1

InChI Key InChIKey=ZVJIOSBCMAOEKO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 398177   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398177(4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(te...)
Affinity DataIC50:  55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398177(4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(te...)
Affinity DataIC50:  300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398177(4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(te...)
Affinity DataIC50:  55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM398177(4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(te...)
Affinity DataIC50:  300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent