BDBM402766 2-[(3S)- or (3R)-azepan-3- ylamino]-N-(2- cyanophenyl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 73

SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(N[C@@H]3CCCCNC3)nn12

InChI Key InChIKey=DKOKBCPJXITPII-OAHLLOKOSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402766   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402766(2-[(3S)- or (3R)-azepan-3- ylamino]-N-(2- cyanophe...)
Affinity DataIC50:  27nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent