BDBM4077 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-6-phenyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::2-[4-(2-Diethylaminoethoxy)phenylamino]-8-ethyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 54

SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1

InChI Key InChIKey=CUAUTGRQMYJPFC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4077   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  31nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  88nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleotide-binding oligomerization domain-containing protein 2(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50:  31nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed