BDBM412702 2,3-Dimethyl-5-(2-(1- methyl-4-phenyl-1H- imidazol-2- yl)ethyl)pyrazolo[1,5- a]pyrimidine::Roche-Dataset for PDE10A, Compound 82::US10399985, Example 16

SMILES Cc1nn2ccc(CCc3nc(cn3C)-c3ccccc3)nc2c1C

InChI Key InChIKey=BKGJKVUEEVHSOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412702   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412702(2,3-Dimethyl-5-(2-(1- methyl-4-phenyl-1H- imidazol...)
Affinity DataIC50:  4.89nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412702(2,3-Dimethyl-5-(2-(1- methyl-4-phenyl-1H- imidazol...)
Affinity DataIC50:  2.40nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent