BDBM412704 (2-Cyclopropyl-6-(2- (1-methyl-4-phenyl- 1H-imidazol-2- yl)ethyl)imidazo[1,2- b]pyridazin-3- yl)methanol::Roche-Dataset for PDE10A, Compound 63::US10399985, Example 18

SMILES Cn1cc(nc1CCc1ccc2nc(C3CC3)c(CO)n2n1)-c1ccccc1

InChI Key InChIKey=MPGHNGMMPLAADB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412704   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412704((2-Cyclopropyl-6-(2- (1-methyl-4-phenyl- 1H-imidaz...)
Affinity DataIC50:  655nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412704((2-Cyclopropyl-6-(2- (1-methyl-4-phenyl- 1H-imidaz...)
Affinity DataIC50:  656nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent