BDBM412706 6-(2-(1-Methyl-4- phenyl-1H-imidazol-2- yl)ethyl)-2- (trifluorome- thyl)imidazo[1,2- b]pyridazine::Roche-Dataset for PDE10A, Compound 25::US10399985, Example 20

SMILES Cn1cc(nc1CCc1ccc2nc(cn2n1)C(F)(F)F)-c1ccccc1

InChI Key InChIKey=JBTWJJMKKOCCCC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412706   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412706(6-(2-(1-Methyl-4- phenyl-1H-imidazol-2- yl)ethyl)-...)
Affinity DataIC50:  83nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412706(6-(2-(1-Methyl-4- phenyl-1H-imidazol-2- yl)ethyl)-...)
Affinity DataIC50:  82.8nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent