BDBM412709 2,3-Dimethyl-6-(2-(1-methyl-4-(pyrimidin-2-yl)-1H-imidazol-2-yl)ethyl)imidazo[1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 291::US10399985, Example 23
SMILES Cc1nc2ccc(CCc3nc(cn3C)-c3ncccn3)nn2c1C
InChI Key InChIKey=CDAFIDKAPLRNPC-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 412709
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 9.18nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 9.20nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info