BDBM412715 2,3-Dimethyl-6-(2-(1- methyl-4-(pyrazin-2- yl)-1H-imidazol-2- yl)ethyl)imidazo[1,2- b]pyridazine::Roche-Dataset for PDE10A, Compound 270::US10399985, Example 29

SMILES Cc1nc2ccc(CCc3nc(cn3C)-c3cnccn3)nn2c1C

InChI Key InChIKey=XSCFJPMNXSUOGM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412715   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412715(2,3-Dimethyl-6-(2-(1- methyl-4-(pyrazin-2- yl)-1H-...)
Affinity DataIC50:  33nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412715(2,3-Dimethyl-6-(2-(1- methyl-4-(pyrazin-2- yl)-1H-...)
Affinity DataIC50:  33.2nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent