BDBM412728 8-Methoxy-3-methyl- 6-((1-methyl-4-phenyl- 1H-imidazol-2- yl)methoxy)-2- (trifluorome- thyl)imidazo[1,2- b]pyridazine::Roche-Dataset for PDE10A, Compound 314::US10399985, Example 41

SMILES COc1cc(OCc2nc(cn2C)-c2ccccc2)nn2c(C)c(nc12)C(F)(F)F

InChI Key InChIKey=UZMQCOLVBSXEAT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412728   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412728(8-Methoxy-3-methyl- 6-((1-methyl-4-phenyl- 1H-imid...)
Affinity DataIC50:  12nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM412728(8-Methoxy-3-methyl- 6-((1-methyl-4-phenyl- 1H-imid...)
Affinity DataIC50:  11.8nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent