BDBM412744 2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine::US10399987, Example 9

SMILES c1cc2c(nc(nc2[nH]1)-c1ccccn1)-n1ccc2cnccc12

InChI Key InChIKey=XTCPFWHYKZIXMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412744   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412744(2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...)
Affinity DataIC50:  150nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412744(2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...)
Affinity DataIC50:  1.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent