BDBM412771 N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)pyridin-2-yl]acetamide::US10399987, Example 36

SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)c1F

InChI Key InChIKey=NTVPLSCCCRJLOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412771   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412771(N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...)
Affinity DataIC50: >1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412771(N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...)
Affinity DataIC50:  1.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent