BDBM412776 N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)pyridin-2-yl]cyclopropanecarboxamide::US10399987, Example 41

SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1

InChI Key InChIKey=RWIZWKXJKLBCDI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412776   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412776(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...)
Affinity DataIC50:  230nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412776(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...)
Affinity DataIC50:  0.870nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent