BDBM413455 (R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-3-yl)-7,9-dihydro-8H-purin-8-one::US10407446, Example 8::US11136340, Example 8

SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1

InChI Key InChIKey=ZXABVFIAHLXSDB-GFCCVEGCSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 413455   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  6.31E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  6.31E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreenŽ Eu Kinase Binding assay run by ThermoFisher Scientific as part of ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  0.398nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent