BDBM414493 2-(2,2- difluoroethoxy)-N- ethyl-N-{2-[4-(1- hydroxy-1- methylethyl)-5- methyl-1,3-oxazol- 2-yl]ethyl}pyridine- 3-carboxamide::US10435398, Example 10

SMILES CCN(CCc1nc(c(C)o1)C(C)(C)O)C(=O)c1cccnc1OCC(F)F

InChI Key InChIKey=ZPEWZAGBKKTSKC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414493   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414493(2-(2,2- difluoroethoxy)-N- ethyl-N-{2-[4-(1- hydro...)
Affinity DataIC50:  1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414493(2-(2,2- difluoroethoxy)-N- ethyl-N-{2-[4-(1- hydro...)
Affinity DataIC50:  224nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent