BDBM414626 US10435405, Example 43::US10934288, Example 43

SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-c1ccc(cc1)N1CCN(C)CC1

InChI Key InChIKey=QPDHLAMWZWYQDQ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 414626   

LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataKi: <1nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM414626(US10435405, Example 43 | US10934288, Example 43)
Affinity DataIC50:  144nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed