BDBM419858 US10464927, Compound I-6

SMILES CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nnc(C(C)C)n4c3)nc2)CC1

InChI Key InChIKey=GASXGKPHRLRSAK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419858   

TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Shanghai Xunhe Pharmaceutical Technology

US Patent
LigandPNGBDBM419858(US10464927, Compound I-6)
Affinity DataIC50:  60nMAssay Description:CDK6: The test compound was dissolved in DMSO and diluted with a kinase buffer solution (20 mM HEPES-pH 7.5, 0.01% Triton X-100, 10 mM MgCl2, 2 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Shanghai Xunhe Pharmaceutical Technology

US Patent
LigandPNGBDBM419858(US10464927, Compound I-6)
Affinity DataIC50: <20nMAssay Description:CDK4: The test compound was dissolved in DMSO and diluted with a kinase buffer solution (20 mM HEPES-pH 7.5, 0.01% Triton X-100, 10 mM MgCl2, 2 mM DT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent