BDBM421072 3-[8-Amino-6-(3-methylisoxazol-5-yl)imidazo[1,2-a]pyrazin-3- yl]-N-(trans-4-hydroxycyclohexyl)-4-methylbenzenesulfonamide::3-[8-Amino-6-(3-methylisoxazol-5-yl)imidazo[1,2-a]pyrazin-3- yl]-N-(trans-4-hydroxycyclohexyl)-4-methylbenzenesulfonamide ::US10479795, Example 75
SMILES Cc1cc(on1)-c1cn2c(cnc2c(N)n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
InChI Key InChIKey=WUIRJOXCRZUUOX-WKILWMFISA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 421072
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: <100nMAssay Description:PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: <100nMAssay Description:PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info