BDBM421075 3-{8-amino-6-[1-(1-cyano-1-methylethyl)-1H-pyrazol-4- yl]imidazo[1,2-a]pyrazin-3-yl}-N-(trans-4-hydroxycyclohexyl)- 4-methylbenzenesulfonamide::3-{8-amino-6-[1-(1-cyano-1-methylethyl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-3-yl}-N-(4-hydroxycyclohexyl)-4-methylbenzenesulfonamide::US10479795, Example 78

SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)-c1cnn(c1)C(C)(C)C#N)S(=O)(=O)NC1CCC(O)CC1

InChI Key InChIKey=JMXWWJZMSGQGMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421075   

LigandPNGBDBM421075(3-{8-amino-6-[1-(1-cyano-1-methylethyl)-1H-pyrazol...)
Affinity DataIC50: <500nMAssay Description:PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM421075(3-{8-amino-6-[1-(1-cyano-1-methylethyl)-1H-pyrazol...)
Affinity DataIC50: <100nMAssay Description:PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent