BDBM423299 US10501452, Compound 5
SMILES CN1CCc2ccc(OCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2C1=O
InChI Key InChIKey=RDGPIFCCGRDXMY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 423299
Affinity DataKi: 0.100nMAssay Description:5-HT2A:(1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:D2:Procedures(1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were m...More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:5-HT1A: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 5.90nMAssay Description:5-HT7: (1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Displacement of [3H](+)8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor stably expressed in CHO cell membranes measured after 30 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 226nMAssay Description:Binding affinity to D3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 991nMAssay Description:Displacement of [3H]prazosin from rat cerebral cortex alpha1 adrenergic receptor measured after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to D1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to H3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to alpha2 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [3H]pyrilamine from guinea pig cerebellum histamine H1 receptor measured after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataKi: 1.69E+3nMAssay Description:Displacement of [3H]mesulergine from rat cerebral cortex 5HT2C receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Histamine H1: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced calcium flux incubated for 60 mins at 3...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jiangsu Ocean University
Curated by ChEMBL
Jiangsu Ocean University
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair